Bourre J M, Piciotti M, Dumont O
Institut National de la Santé et de la Recherche Médicale, U26 Hopital Fernand Widal, Paris, France.
Lipids. 1990 Jun;25(6):354-6. doi: 10.1007/BF02544347.
delta 6 Desaturase was measured in the mouse brain and liver using linoleic acid as substrate. During pre- and postnatal development, delta 6 desaturase in brain decreased dramatically (12-fold) up to postnatal day 21 and remained nearly constant thereafter. In liver, the activity increased approximately 9-fold between day 3 before birth and day 7 after birth. Then it decreased slightly up to weaning and was approximately constant up to 4 mo. From then on, delta 6 desaturase decreased with age (40% between 4 and 17 mo).
以亚油酸为底物，在小鼠脑和肝脏中测定了Δ6去饱和酶。在出生前和出生后的发育过程中，脑内的Δ6去饱和酶在出生后第21天之前急剧下降（12倍），此后几乎保持恒定。在肝脏中，活性在出生前3天到出生后7天之间增加了约9倍。然后在断奶前略有下降，直到4个月时大致保持恒定。从那时起，Δ6去饱和酶随年龄下降（4至17个月之间下降40%）。
