胃泌素在先天性肥厚性幽门狭窄中的作用。
The role of gastrin in congenital hypertrophic pyloric stenosis.
作者信息
Janik J S, Akbar A M, Burrington J D, Burke G
出版信息
J Pediatr Surg. 1978 Apr;13(2):151-4. doi: 10.1016/s0022-3468(78)80009-8.
PMID:650365
Abstract
A study was designed and carried out to determine if the canine model of hypertrophic pyloric stenosis is applicable to other species and to demonstrate the transplacental passage of gastrin. Results of the study show that (1) pentagastrin does not induce hypertrophic pyloric stenosis in the rabbit; (2) human gastrin does not cross the canine placenta, and (3) gastrin has no documented and little inferred role in the etiology of CHPS.
摘要
设计并开展了一项研究，以确定肥厚性幽门狭窄的犬类模型是否适用于其他物种，并证明胃泌素的胎盘转运情况。该研究结果表明：（1）五肽胃泌素不会在兔身上诱发肥厚性幽门狭窄；（2）人胃泌素不会穿过犬类胎盘；（3）胃泌素在先天性肥厚性幽门狭窄的病因中没有已记录的作用，推断的作用也很小。
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