Klevay L M, Inman L, Johnson L K, Lawler M, Mahalko J R, Milne D B, Lukaski H C, Bolonchuk W, Sandstead H H
Metabolism. 1984 Dec;33(12):1112-8. doi: 10.1016/0026-0495(84)90096-9.
Signs of copper depletion were produced in a healthy man by an amount of dietary copper (0.83 mg/day) similar to that in some contemporary diets. Urinary and fecal loss of copper exceeded intake. Plasma copper, ceruloplasmin, and superoxide dismutase activity in erythrocytes decreased. Cholesterol in plasma increased, and hematologic indices were unchanged. Lipid metabolism may be a more sensitive index of copper nutriture than are changes in hematology. The findings support the hypothesis that inadequate copper nutriture or altered copper metabolism contributes to the occurrence of ischemic heart disease.
一名健康男性通过摄入与一些现代饮食中相似量的膳食铜（0.83毫克/天）出现了铜缺乏的迹象。铜的尿排泄和粪排泄超过了摄入量。血浆铜、铜蓝蛋白和红细胞中的超氧化物歧化酶活性降低。血浆胆固醇升高，血液学指标未发生变化。与血液学变化相比，脂质代谢可能是铜营养状况更敏感的指标。这些发现支持了以下假设：铜营养不足或铜代谢改变会导致缺血性心脏病的发生。
