Medeiros D M, Milton A, Brunett E, Stacy L
Department of Home Economics, School of Pharmacy, University of Wyoming, Laramie 82071.
Biol Trace Elem Res. 1991 Jul;30(1):19-35. doi: 10.1007/BF02990339.
Two 6-wk double-blind studies evaluated the effects of supplements of 2 or 3 mg Cu/d on serum copper, ceruloplasmin, red-blood-cell super oxide dismutase (RBC-SOD), total serum cholesterol, and serum lipoprotein-cholesterol fractions in adult males. Study I had 6 supplemented and 8 placebo subjects, whereas study II had 7 and 6, respectively. Copper supplementation did not appear to affect serum copper levels, RBC-SOD, hematocrit, and ceruloplasmin levels when assayed by radial immunoassay diffusion. Supplementation with 2 mg Cu/d produced an increase in LDL cholesterol and the percentage of cholesterol as LDL at wk 4 compared to the placebo group, and a concomitant decline in VLDL-cholesterol levels and the percentage of cholesterol as VLDL. At wk 6, the percentage of cholesterol as LDL increased and that of cholesterol as VLDL decreased compared to baseline values in the supplemented group. Supplements of 3 mg Cu/d increased hemoglobin levels, ceruloplasmin activity, and serum total-cholesterol levels at wk 6 compared to placebos. Differences in cholesterol may be partly explained by variability in the placebo groups in both studies. Copper supplementation effects on cholesterol deserves further investigation.
两项为期6周的双盲研究评估了每日补充2毫克或3毫克铜对成年男性血清铜、铜蓝蛋白、红细胞超氧化物歧化酶（RBC-SOD）、血清总胆固醇以及血清脂蛋白胆固醇组分的影响。研究I有6名补充铜的受试者和8名服用安慰剂的受试者，而研究II分别有7名和6名。通过放射免疫扩散法测定时，补充铜似乎并未影响血清铜水平、RBC-SOD、血细胞比容和铜蓝蛋白水平。与安慰剂组相比，每日补充2毫克铜使第4周时低密度脂蛋白胆固醇（LDL胆固醇）以及LDL胆固醇占总胆固醇的百分比增加，同时极低密度脂蛋白胆固醇（VLDL胆固醇）水平以及VLDL胆固醇占总胆固醇的百分比下降。在第6周时，与补充组的基线值相比，LDL胆固醇占总胆固醇的百分比增加，VLDL胆固醇占总胆固醇的百分比下降。与安慰剂相比，每日补充3毫克铜使第6周时血红蛋白水平、铜蓝蛋白活性和血清总胆固醇水平升高。两项研究中安慰剂组的变异性可能部分解释了胆固醇方面的差异。补充铜对胆固醇的影响值得进一步研究。
