在腺相关病毒DNA复制中，构象比序列更重要。
Conformation takes precedence over sequence in adeno-associated virus DNA replication.
作者信息
Lefebvre R B, Riva S, Berns K I
出版信息
Mol Cell Biol. 1984 Jul;4(7):1416-9. doi: 10.1128/mcb.4.7.1416-1419.1984.
Abstract
Deletion of an 11-base symmetrical sequence in the inverted terminal repetition of the adeno-associated virus 2 genome inhibits DNA replication. Substitution of either an 8- or a 12-base symmetrical sequence unrelated to the original 11-base sequence restores DNA replication.
摘要
腺相关病毒2型基因组反向末端重复序列中一个11碱基对称序列的缺失会抑制DNA复制。用与原始11碱基序列无关的8碱基或12碱基对称序列进行替换可恢复DNA复制。
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