Prasad A S
Prog Clin Biol Res. 1984;165:49-58.
Occurrence of zinc deficiency in adult sickle cell anemia subjects has been reported previously. Improvement in secondary sexual characteristics, normalization of plasma ammonia and serum testosterone levels, and reversal of dark adaptation abnormality and anergy following zinc supplementation to sickle cell anemia subjects have been observed. In this paper we report the results of a controlled trial with zinc supplementation in 14 to 19 year old sickle cell anemia subjects who were retarded in growth. Our data show that zinc supplementation significantly improved longitudinal growth and body weight in these subjects.
此前已有报道称成年镰状细胞贫血患者会出现锌缺乏的情况。观察到对镰状细胞贫血患者补充锌后，其第二性征得到改善，血浆氨和血清睾酮水平恢复正常，暗适应异常和无反应性也得到了逆转。在本文中，我们报告了一项针对14至19岁生长发育迟缓的镰状细胞贫血患者进行锌补充的对照试验结果。我们的数据表明，补充锌显著改善了这些患者的纵向生长和体重。
