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钙拮抗剂对吗啡体温调节和镇痛作用的增强作用。

Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists.

作者信息

Benedek G, Szikszay M

出版信息

Pharmacol Res Commun. 1984 Oct;16(10):1009-18. doi: 10.1016/s0031-6989(84)80065-x.

DOI:10.1016/s0031-6989(84)80065-x
PMID:6504960
Abstract

Diltiazem, a calcium slow channel blocker, greatly potentiated and prolonged the antinociceptive effect of morphine in rats. Hypothermia, the primary thermoregulatory effect of morphine, was also potentiated. Verapamil, another calcium blocker elicited corresponding changes in the analgetic and thermoregulatory effects of morphine. These findings seem to be in concert with the suggestions that opiate effects on thermoregulation and nociception are exerted via modulation of calcium fluxes across neural membranes.

摘要

地尔硫䓬，一种钙慢通道阻滞剂，极大地增强并延长了吗啡对大鼠的镇痛作用。体温过低，吗啡的主要体温调节作用，也被增强了。维拉帕米，另一种钙阻滞剂，在吗啡的镇痛和体温调节作用方面引发了相应的变化。这些发现似乎与以下观点一致，即阿片类药物对体温调节和痛觉的作用是通过调节跨神经细胞膜的钙通量来实现的。

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