维拉帕米可减轻右美托咪定诱导的大鼠脑血流量降低：一项激光多普勒研究

Dexmedetomidine-induced decrease in cerebral blood flow is attenuated by verapamil in rats: a laser Doppler study.

作者信息

Bari F, Horváth G, Benedek G

机构信息

Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.

出版信息

Can J Anaesth. 1993 Aug;40(8):748-54. doi: 10.1007/BF03009771.

DOI:10.1007/BF03009771

PMID:8104728

Abstract

This study was performed to examine the changes in local cortical blood flow (CoBF) after simultaneous administration of an alpha 2 adrenergic agonist (dexmedetomidine) and a calcium channel antagonist (verapamil) to urethane-anaesthetized rats. Dexmedetomidine (100 micrograms.kg-1) given intraperitoneally alone resulted in decreases in mean arterial blood pressure (MABP) (F[27,140] = 3.43; P < 0.01) and CoBF (F[27,140] = 4.22; P < 0.01), whereas the heart rate (HR) was increased (F[27,140] = 2.33; P < 0.01). Verapamil (2.5 mg.kg-1) given subcutaneously reduced the MABP (F[27,140] = 3.41; P < 0.01), but the HR and CoBF were not changed. Combined administration of the drugs decreased MAPB (F[27,140] = 5.37; P < 0.01), with no changes in CoBF and HR. The present data indicate that the calcium channel antagonist verapamil did not potentiate the haemodynamic effects of dexmedetomidine in rats, but rather attenuated the effect of dexmedetomidine on CoBF. This favourable interaction suggests a potential therapeutic role of these agents in maintaining cardiovascular stability during surgical interventions.

摘要

本研究旨在检测在给乌拉坦麻醉的大鼠同时给予α2肾上腺素能激动剂（右美托咪定）和钙通道拮抗剂（维拉帕米）后局部皮质血流（CoBF）的变化。单独腹腔注射右美托咪定（100微克·千克-1）导致平均动脉血压（MABP）降低（F[27,140] = 3.43；P < 0.01）和CoBF降低（F[27,140] = 4.22；P < 0.01），而心率（HR）增加（F[27,140] = 2.33；P < 0.01）。皮下注射维拉帕米（2.5毫克·千克-1）可降低MABP（F[27,140] = 3.41；P < 0.01），但HR和CoBF未改变。联合给药可降低MAPB（F[27,140] = 5.37；P < 0.01），CoBF和HR无变化。目前的数据表明，钙通道拮抗剂维拉帕米不会增强右美托咪定对大鼠的血流动力学效应，反而会减弱右美托咪定对CoBF的作用。这种有利的相互作用表明这些药物在手术干预期间维持心血管稳定性方面具有潜在的治疗作用。