Drago F, Continella G, Alloro M C, Auditore S, Pennisi G
Pharmacol Res Commun. 1984 Sep;16(9):899-907. doi: 10.1016/s0031-6989(84)80026-0.
The effects of aminoacid arginine on conditioned and unconditioned behavior were studied in male rats. Arginine was administered orally at different dose levels. Both acute and subchronic (7 days) treatment schedule was performed. Exploratory behavior of the rats was studied in an open field. Acquisition of active avoidance behavior was studied in the shuttle-box test situation, and retention of passive avoidance reaction was studied in a step-through type of passive avoidance behavior. Acute administration of arginine failed to affect the acquisition and the retention of avoidance responses, and exploratory behavior of the rats. A 7-day treatment with the aminoacid caused an increase in ambulation of rats of Wistar strain, and a facilitation of acquisition and retention of avoidance responses in rats of CDR strain with poor learning capacity. It is possible that behavioral effects or arginine depend on its involvement in nucleic acid synthesis.
在雄性大鼠中研究了氨基酸精氨酸对条件性和非条件性行为的影响。以不同剂量水平经口给予精氨酸。进行了急性和亚慢性（7天）治疗方案。在旷场中研究大鼠的探究行为。在穿梭箱试验情境中研究主动回避行为的习得，在穿梭式被动回避行为中研究被动回避反应的保持。急性给予精氨酸未能影响大鼠回避反应的习得和保持以及探究行为。用该氨基酸进行7天治疗使Wistar品系大鼠的行走增加，并促进了学习能力较差的CDR品系大鼠回避反应的习得和保持。精氨酸的行为效应可能取决于其参与核酸合成的情况。
