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静脉注射钆喷酸葡胺/葡甲胺后在健康志愿者体内的药代动力学。

Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers.

作者信息

Weinmann H J, Laniado M, Mützel W

出版信息

Physiol Chem Phys Med NMR. 1984;16(2):167-72.

PMID:6505043
Abstract

Pharmacokinetic studies of GdDTPA/dimeglumine in man show a rapid renal clearance and no evidence for dissociation or retention of the complex in the body. These features, in conjunction with its strong proton relaxation enhancement and its low toxicity suggest that this complex may be an excellent contrast medium for magnetic resonance imaging.

摘要

钆喷酸葡胺/葡甲胺在人体中的药代动力学研究表明,其经肾脏快速清除,且无证据表明该复合物在体内会解离或潴留。这些特性,再加上其强大的质子弛豫增强作用和低毒性,表明该复合物可能是一种用于磁共振成像的极佳造影剂。

相似文献

1
Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers.静脉注射钆喷酸葡胺/葡甲胺后在健康志愿者体内的药代动力学。
Physiol Chem Phys Med NMR. 1984;16(2):167-72.
2
First use of GdDTPA/dimeglumine in man.钆喷酸葡胺/葡甲胺在人体中的首次应用。
Physiol Chem Phys Med NMR. 1984;16(2):157-65.
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[Anaphylactoid reaction caused by intravenous gadopentetate dimeglumine in magnetic resonance].磁共振成像中静脉注射钆喷酸葡胺引起的类过敏反应
Med Clin (Barc). 1996 Feb 10;106(5):197.
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Hemodynamic effects of gadodiamide injection and gadopentetate dimeglumine in anesthetized dogs.钆双胺注射液和钆喷酸葡胺对麻醉犬的血流动力学影响。
Acta Radiol. 1993 Sep;34(5):510-6.
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Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent.钆-DTPA 复合物的特性:一种潜在的核磁共振造影剂。
AJR Am J Roentgenol. 1984 Mar;142(3):619-24. doi: 10.2214/ajr.142.3.619.
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Gadolinium-DTPA: a new contrast agent for magnetic resonance imaging.
Radiat Med. 1985 Jan-Mar;3(1):7-12.
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Gadolinium DTPA (an NMR proton imaging contrast agent): chemical structure, paramagnetic properties and pharmacokinetics.钆喷酸葡胺(一种核磁共振质子成像造影剂):化学结构、顺磁特性及药代动力学
Physiol Chem Phys Med NMR. 1984;16(2):97-104.
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MR imaging of pituitary region lesions with gadodiamide injection.钆双胺注射剂用于垂体区域病变的磁共振成像。
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MR imaging of the breast. Imaging and tissue characterization without intravenous contrast.乳腺的磁共振成像。无需静脉注射造影剂的成像与组织特征分析。
Magn Reson Imaging Clin N Am. 1994 Nov;2(4):673-90.
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The effect of Gd-dimeglumine on subcutaneous tissues: a study with rats.钆喷酸葡胺对皮下组织的影响:一项大鼠研究。
AJNR Am J Neuroradiol. 1990 Mar-Apr;11(2):325-7.

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