静脉注射钆喷酸葡胺/葡甲胺后在健康志愿者体内的药代动力学。
Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers.
作者信息
Weinmann H J, Laniado M, Mützel W
出版信息
Physiol Chem Phys Med NMR. 1984;16(2):167-72.
PMID:6505043
Abstract
Pharmacokinetic studies of GdDTPA/dimeglumine in man show a rapid renal clearance and no evidence for dissociation or retention of the complex in the body. These features, in conjunction with its strong proton relaxation enhancement and its low toxicity suggest that this complex may be an excellent contrast medium for magnetic resonance imaging.
摘要
钆喷酸葡胺/葡甲胺在人体中的药代动力学研究表明，其经肾脏快速清除，且无证据表明该复合物在体内会解离或潴留。这些特性，再加上其强大的质子弛豫增强作用和低毒性，表明该复合物可能是一种用于磁共振成像的极佳造影剂。
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