Castonguay T W, Burdick S L, Guzman M A, Collier G H, Stern J S
Physiol Behav. 1984 Jul;33(1):119-26. doi: 10.1016/0031-9384(84)90022-2.
Adult female lean and obese Zucker rats were allowed to compose their own diets by giving them access to three macronutrient sources. After a baseline period, the fat source was serially diluted. In all, eight concentrations of fat were used. Dilution of the fat source promoted significant increases in the intake of fat by both lean and obese rats. The increased intake of fat was not simply compensatory in nature, but rather represented significant increases in fat consumption. These results suggest that the reported increased appetite for fat of the obese rat is not a unique trait of that genotype. Further, results from this experiment demonstrate that caloric and protein regulation mechanisms may not be controlling the intake of obese and lean rats as precisely as once believed.
成年雌性瘦型和肥胖型 Zucker 大鼠通过给予三种常量营养素来源来让它们自行选择饮食。在基线期之后，脂肪来源被逐步稀释。总共使用了八种脂肪浓度。脂肪来源的稀释促使瘦型和肥胖型大鼠的脂肪摄入量均显著增加。脂肪摄入量的增加并非简单的补偿性质，而是代表脂肪消耗量的显著增加。这些结果表明，所报道的肥胖大鼠对脂肪食欲增加并非该基因型的独特特征。此外，该实验结果表明，热量和蛋白质调节机制对肥胖型和瘦型大鼠摄入量的控制可能并不像曾经认为的那样精确。
