Xu F X, van der Schueren E, Ang K K
Radiother Oncol. 1984 Mar;1(4):369-74. doi: 10.1016/s0167-8140(84)80025-0.
The acute reaction of the lip mucosa of mice after single and fractionated irradiations has been investigated. The mouths of 24 mice were irradiated simultaneously in a single field. It was found that the acute reaction of lip mucosa can easily and reliably be scored. The variation in scoring between different observers is small and the reaction is reproducible. The mucosal reaction starts at day 7, reaches a maximum at about day 11-12 and regresses rapidly during the following 6 to 7 days. The overall reaction period is thus shorter for lip mucosa than for skin in the mouse, indicating a shorter cell cycle time. Dose-response curves can be constructed by plotting the average reaction from day 8 to 17 versus the total dose. The curve of log isoeffect dose for an average reaction level 3 against log number of fractions has a slope of 0.35 for a dose rate of 200 cGy/min and 0.29 for 33 cGy/min. The dose required to induce focal mucosa desquamation is significantly lower than that necessary to produce spotted epidermolysis in skin (16.5 Gy vs. 33 Gy for single dose).
对小鼠唇部黏膜单次及分次照射后的急性反应进行了研究。24只小鼠的口腔在单个照射野中同时接受照射。结果发现，唇部黏膜的急性反应易于且可靠地进行评分。不同观察者之间的评分差异很小，且反应具有可重复性。黏膜反应在第7天开始，在大约第11 - 12天达到最大值，并在随后的6至7天内迅速消退。因此，小鼠唇部黏膜的总体反应期比皮肤短，表明细胞周期时间更短。通过绘制第8天至第17天的平均反应与总剂量的关系曲线，可以构建剂量反应曲线。对于平均反应水平为3的情况，对数等效应剂量曲线与分次照射次数的对数曲线，在剂量率为200 cGy/min时斜率为0.35，在33 cGy/min时斜率为0.29。诱导局灶性黏膜脱屑所需的剂量明显低于引起皮肤点状表皮松解所需的剂量（单次剂量分别为16.5 Gy和33 Gy）。
