Grenabo L, Holmlund D
Scand J Urol Nephrol. 1984;18(4):325-7. doi: 10.3109/00365598409180203.
In a prospective, randomized study, the prophylactic effect of indomethacin (150 mg daily) in regard to recurrence of ureteral colic was investigated in 78 patients. Severe recurrent attacks were experienced in 78 patients. Severe recurrent attacks were experienced by 4 of 37 patients in the test group and by 16 of the 41 controls without indomethacin. The mean duration of recurrent pain including the severe attacks was 5.6 +/- 1.1 hour/patient/week in the test group and 12.5 +/- 2.9 in the control group. Passage of stone within 7 days was not influenced by indomethacin (22/37 and 25/41 cases). Indomethacin administration for 7 days after an acute attack of ureteral colic thus reduced the frequency of severe attacks and the total duration of recurrent pain, without influencing the stone passage.
在一项前瞻性随机研究中，对78例患者研究了吲哚美辛（每日150毫克）对输尿管绞痛复发的预防作用。78例患者经历了严重的复发发作。试验组37例患者中有4例经历了严重的复发发作，41例未使用吲哚美辛的对照组中有16例经历了严重的复发发作。试验组包括严重发作在内的复发性疼痛的平均持续时间为5.6±1.1小时/患者/周，对照组为12.5±2.9小时/患者/周。结石在7天内排出不受吲哚美辛影响（试验组22/37例，对照组25/41例）。因此，输尿管绞痛急性发作后给予吲哚美辛7天可减少严重发作的频率和复发性疼痛的总持续时间，而不影响结石排出。
