Sjödin J G, Holmlund D
Scand J Urol Nephrol. 1982;16(3):221-5. doi: 10.3109/00365598209179757.
In a multicentre study the analgetic effect of indomethacin in ureteral colic was analyzed. Indomethacin, which inhibits the synthesis of prostaglandin, was given by intravenous infusion in a dose of 50 mg. The study comprised 198 patients with 252 attacks of ureteral colic. Satisfactory relief of pain was obtained in 212 attacks (84%). No serious side effects of indomethacin were observed. The pain recurred within four hours in only 15 patients (7%), in 12 of them during a diagnostic intravenous pyelography. The relief of pain may be explained by reduced glomerular filtration pressure and/or diminished urinary excretion, causing rapid fall in the renal pelvic pressure and in the tension of the pelvi-ureteral wall. A low extracellular volume of fluid in a patient with ureteral colic may be essential for analgetic action of indomethacin.
在一项多中心研究中，分析了吲哚美辛对输尿管绞痛的镇痛效果。吲哚美辛可抑制前列腺素的合成，以50毫克的剂量静脉输注给药。该研究纳入了198例患者，共发生252次输尿管绞痛发作。212次发作（84%）的疼痛得到了满意缓解。未观察到吲哚美辛的严重副作用。仅15例患者（7%）在4小时内疼痛复发，其中12例是在诊断性静脉肾盂造影期间复发。疼痛缓解可能是由于肾小球滤过压降低和/或尿排泄减少，导致肾盂压力和肾盂输尿管壁张力迅速下降。输尿管绞痛患者细胞外液量较低可能是吲哚美辛产生镇痛作用的关键。
