Montesco M C, Pluchinotta A, Piffanelli A, Pelizzola D, Giovannini G, Pagnini C A
Tumori. 1984 Oct 31;70(5):445-50. doi: 10.1177/030089168407000510.
The possible relationships between hormone receptor status and several clinical (age, gynecologic history, clinical stage) and morphologic aspects (histologic grade, vascular invasion, lymphocytic infiltration, necrosis, fibrosis, elastosis and lymph node metastasis) were evaluated. A highly significant correlation between estrogen receptor levels, patient age, menses regularity and postmenopausal status was found. The histologic features most significantly related to tumor receptor status were histologic grade, lymphocytic infiltrate, necrosis and elastosis. Since these same histologic aspects appear to influence prognosis in breast cancer, the prognostic significance attributed to tumor receptor levels is substantiated. Therefore the importance of this assay is confirmed, not only for its diagnostic and therapeutic purposes, but also for its prognostic value.
评估了激素受体状态与几种临床（年龄、妇科病史、临床分期）和形态学方面（组织学分级、血管侵犯、淋巴细胞浸润、坏死、纤维化、弹性组织变性和淋巴结转移）之间的可能关系。发现雌激素受体水平、患者年龄、月经规律性和绝经状态之间存在高度显著的相关性。与肿瘤受体状态最显著相关的组织学特征是组织学分级、淋巴细胞浸润、坏死和弹性组织变性。由于这些相同的组织学方面似乎影响乳腺癌的预后，因此归因于肿瘤受体水平的预后意义得到了证实。因此，该检测方法的重要性得到了确认，不仅因其诊断和治疗目的，还因其预后价值。
