Trail P A, Yang T J, Cameron J A
Vet Immunol Immunopathol. 1984 Oct;7(3-4):359-68. doi: 10.1016/0165-2427(84)90093-x.
Cyclic haematopoiesis (CH) is an inherited disorder which occurs in both humans and Grey Collie dogs. The disease is characterized by fluctuations in the numbers of peripheral blood leucocytes, reticulocytes and platelets at regular intervals and is associated with a variety of clinical signs. The most prominent cycle observed is that of neutrophils. The 12-day neutropenic cycle includes a period of relatively normal neutrophil counts, a period of neutropenia and generally a period in which neutrophil counts greatly exceed the normal range. In this study the daily serum haemolytic complement activity (classical pathway CH50) of CH and normal Collie dogs was assayed. The serum CH50 of normal Collie dogs was relatively stable throughout the test period. In contrast, the serum CH50 of CH dogs fluctuated extensively and the mean serum CH50 of CH dogs during the neutropenic cycle greatly exceeded that of normal Collie dogs over the same test period. A close temporal relationship between the stage of the CH neutropenic cycle and the serum CH50 was observed. The mean serum CH50 during neutropenia was not significantly different from that observed when neutrophil counts were within normal range, both values being significantly higher than that of normal dogs. However, the mean serum CH50 during the period of neutrophil rebound was significantly (P less than 0.01) higher than that during the period of neutropenia or normal neutrophil counts. These data suggest that alterations in the production of complement components or regulatory proteins occur at regular intervals in CH dogs.
循环性造血（CH）是一种遗传性疾病，在人类和灰色柯利犬中均有发生。该疾病的特征是外周血白细胞、网织红细胞和血小板数量有规律地波动，并伴有多种临床症状。观察到的最明显的周期是中性粒细胞的周期。12天的中性粒细胞减少周期包括中性粒细胞计数相对正常的时期、中性粒细胞减少的时期，通常还有中性粒细胞计数大大超过正常范围的时期。在本研究中，对患有CH的柯利犬和正常柯利犬的每日血清溶血补体活性（经典途径CH50）进行了测定。在整个测试期间，正常柯利犬的血清CH50相对稳定。相比之下，患有CH的犬的血清CH50波动很大，并且在中性粒细胞减少周期期间，患有CH的犬的平均血清CH50在相同测试期间大大超过了正常柯利犬的平均血清CH50。观察到CH中性粒细胞减少周期的阶段与血清CH50之间存在密切的时间关系。中性粒细胞减少期间的平均血清CH50与中性粒细胞计数在正常范围内时观察到的平均血清CH50没有显著差异，这两个值均显著高于正常犬的值。然而，中性粒细胞反弹期间的平均血清CH50显著（P小于0.01）高于中性粒细胞减少期或中性粒细胞计数正常期间的平均血清CH50。这些数据表明，患有CH的犬体内补体成分或调节蛋白的产生会定期发生变化。
