Dale D C, Ward S B, Kimball H R, Wolff S M
J Clin Invest. 1972 Aug;51(8):2190-6. doi: 10.1172/JCI107026.
12 grey collie dogs had cyclic neutropenia with the neutropenia recurring at 11.8+/-0.1-day intervals. The recovery from neutropenia was accompanied by a single wave of myeloid proliferation, an increase in marrow myeloid-labeling indices, and an increase in serum muramidase levels. After recovery from neutropenia during the period when blood neutrophils (PMN) were normal or increased, marrow myeloid precursors became scarce. The decline in marrow precursors and marrow PMN reserves heralded the recurrence of neutropenia. Neither diisopropyl fluorophosphate (DF(32)P) leukokinetic studies nor the rate of development of neutropenia suggested shortened PMN survival as a mechanism for the neutropenia. These studies indicate that the cyclic neutropenia is due to a regularly recurring failure in PMN production.
12只灰色柯利犬患有周期性中性粒细胞减少症，中性粒细胞减少症以11.8±0.1天的间隔反复出现。从中性粒细胞减少症恢复伴随着单一的髓系增殖波、骨髓髓系标记指数增加以及血清溶菌酶水平升高。在中性粒细胞减少症恢复后，当血液中性粒细胞（PMN）正常或增加时，骨髓髓系前体细胞变得稀少。骨髓前体细胞和骨髓PMN储备的减少预示着中性粒细胞减少症的复发。二异丙基氟磷酸酯（DF(32)P）白细胞动力学研究和中性粒细胞减少症的发展速率均未表明PMN存活时间缩短是中性粒细胞减少症的机制。这些研究表明，周期性中性粒细胞减少症是由于PMN生成中定期反复出现的故障所致。
