弗里德赖希共济失调中红细胞膜磷脂的异常。
Abnormalities of the erythrocyte membrane phospholipids in Friedreich's ataxia.
作者信息
Firenze C, Trovarelli G, Gallai V, De Medio G E, Porcellati G
出版信息
Acta Neurol Scand. 1984 Sep;70(3):197-200. doi: 10.1111/j.1600-0404.1984.tb00819.x.
The phospholipid composition and the fatty acids of the phospholipids in the erythrocyte membranes were studied in 5 patients with Friedreich's ataxia. The sphingomyelin content was found to be insignificantly reduced, that of phophatidylethanolamine was, on the contrary, increased even if non-significantly. The linoleic acid content was significantly decreased both in the total fraction of the phospholipids and in the isolated phosphatidylcholine. The relationship between the phospholipid composition and the structure and function of the membrane are discussed.
对5例弗里德赖希共济失调患者红细胞膜中的磷脂组成及磷脂脂肪酸进行了研究。发现鞘磷脂含量略有降低，相反，磷脂酰乙醇胺含量即使不显著也有所增加。磷脂总组分及分离出的磷脂酰胆碱中的亚油酸含量均显著降低。文中讨论了磷脂组成与膜的结构和功能之间的关系。
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