Lowe D M, Moore M N
J Natl Cancer Inst. 1978 Jun;60(6):1455-9. doi: 10.1093/jnci/60.6.1455.
Proliferative lesions were found in 16 of 994 Mytilus edulis mussels obtained from the mouth of the River Lynher at Plymouth, England. These lesions were characterized by infiltration and replacement of the connective tissue by enlarged, atypical, mitotically active, basophilic, hemocyte-like cells. Cytologic examination indicated the involvement of two cell types in this disorder, both of which were similar in appearance to the much smaller, normal basophallic agranular hemocyte. The abnormal cells were rich in cytoplasmic RNA and had significantly higher DNA levels than normal hemocytes as determined by scanning microdensitometry. A few of the atypical cells contained small cytoplasmic granules that were positive for lysosomal hydrolases. This condition was observed sequentially from what is believed to be the earliest stage of the disease, in which only a few atypical cells were present, to the terminal stage, in which the connective tissue was almost completely replaced and the digestive gland cells were necrotized. Some potentially carcinogenic aromatic hydrocarbons have been identified in the substrate of the mussel bed by gas-liquid chromatography-mass spectrometry analysis.
在从英国普利茅斯林赫河口采集的994只蓝贻贝中，有16只发现了增殖性病变。这些病变的特征是结缔组织被增大的、非典型的、有丝分裂活跃的、嗜碱性的、血细胞样细胞浸润并取代。细胞学检查表明，这种疾病涉及两种细胞类型，这两种细胞在外观上都与小得多的正常嗜碱性无颗粒血细胞相似。通过扫描显微密度测定法确定，异常细胞富含细胞质RNA，DNA水平明显高于正常血细胞。一些非典型细胞含有小的细胞质颗粒，这些颗粒对溶酶体水解酶呈阳性。从被认为是疾病最早阶段（仅存在少数非典型细胞）到末期阶段（结缔组织几乎完全被取代，消化腺细胞坏死），依次观察到了这种情况。通过气-液色谱-质谱分析，在贻贝床的基质中鉴定出了一些潜在致癌的芳香烃。
