Homma S, Matsumoto T, Abe H, Fukuda Y, Nagano M, Suzuki M
Acta Pathol Jpn. 1984 Sep;34(5):1137-46. doi: 10.1111/j.1440-1827.1984.tb07641.x.
Relapsing polychondritis (RP) is a disorder of unknown etiology characterized by the destruction of cartilage. A case of RP in a 59-year-old male was autopsied, and systemic inflammation of various cartilages was confirmed. We demonstrated the circulating antibodies to Type II (cartilage) collagen. No antibodies to other collagen types were demonstrated. The presence of granular deposits of immunoglobulins, fibrinogen, and the C3 component of complement at the chondrofibrous junction was also demonstrated. From these findings, this case suggested that the pathogenesis of RP is related to an immune mechanism.
复发性多软骨炎（RP）是一种病因不明的以软骨破坏为特征的疾病。对一名59岁男性的RP病例进行了尸检，证实了全身各种软骨的炎症。我们检测到了针对II型（软骨）胶原蛋白的循环抗体。未检测到针对其他胶原蛋白类型的抗体。同时还证实了在软骨纤维交界处存在免疫球蛋白、纤维蛋白原和补体C3成分的颗粒状沉积物。从这些发现来看，该病例提示RP的发病机制与免疫机制有关。
