Grey V L, Garofalo C, Greenberg G R, Morin C L
Am J Clin Nutr. 1984 Dec;40(6):1235-42. doi: 10.1093/ajcn/40.6.1235.
The effects of long-chain triglycerides and a mixture of free fatty acid on the adaptive response to small bowel resection were examined. Rats with a 50% small bowel resection were divided into four groups. Two received 10% of their calories intragastrically either as corn oil or as free fatty acid and the remaining calories intravenously while the two control groups were given all their calories either intravenously or orally. The results of DNA and protein determination show that free fatty acids were more effective than long-chain triglyceride in promoting adaptation (p less than 0.01) in both small intestine and in the colon. Furthermore the intragastric infusion of free fatty acids was as effective as the orally fed group. Of the plasma hormones measured (gastrin, gastric inhibitory polypeptide, enteroglucagon, and insulin) gastric inhibitory polypeptide was significantly higher (p less than 0.05) in the orally fed group and insulin levels in the free fatty acid group (p less than 0.05) than in other groups. There was no significant difference obtained in enteroglucagon and gastrin levels for the four groups. This study shows that a small amount of free fatty acids (10% of the total calories) given by continuous gastric infusion is effective in promoting intestinal adaptation after resection.
研究了长链甘油三酯和游离脂肪酸混合物对小肠切除术后适应性反应的影响。将50%小肠切除的大鼠分为四组。两组大鼠通过胃内给予10%的热量，分别以玉米油或游离脂肪酸的形式，其余热量通过静脉给予，而两个对照组则分别通过静脉或口服给予所有热量。DNA和蛋白质测定结果表明，游离脂肪酸在促进小肠和结肠的适应性方面比长链甘油三酯更有效（p<0.01）。此外，胃内输注游离脂肪酸与口服喂养组的效果相同。在所测量的血浆激素（胃泌素、胃抑制性多肽、肠高血糖素和胰岛素）中，口服喂养组的胃抑制性多肽显著更高（p<0.05），游离脂肪酸组的胰岛素水平（p<0.05）高于其他组。四组的肠高血糖素和胃泌素水平没有显著差异。这项研究表明，通过持续胃内输注给予少量游离脂肪酸（占总热量的10%）对促进切除术后的肠道适应性是有效的。
