Child C S
Anaesthesia. 1984 Nov;39(11):1083-5. doi: 10.1111/j.1365-2044.1984.tb08927.x.
Colonic intraluminal pressure was recorded in eight patients receiving either atropine 1.2 mg (n = 4) or glycopyrronium 0.6 mg (n = 4) intravenously in a randomised, double-blind fashion and followed after 5 minutes by neostigmine 2.5 mg. Estimations of total colonic activity were made from the area under the recording of intraluminal pressure. There were no significant differences in mean intraluminal pressures or total colonic activity between the two groups. It is concluded that glycopyrronium offers no advantage over atropine with respect to protection of the bowel against the effects of neostigmine.
对8例患者进行结肠腔内压力记录，这些患者以随机、双盲方式静脉注射1.2毫克阿托品（n = 4）或0.6毫克格隆溴铵（n = 4），5分钟后注射2.5毫克新斯的明。根据腔内压力记录下的面积对结肠总活性进行评估。两组之间的平均腔内压力或结肠总活性无显著差异。得出的结论是，在保护肠道免受新斯的明影响方面，格隆溴铵并不比阿托品更具优势。
