Horst H A, Horny H P, Gent H J, Sellschopp C, Hedderich J
Abteilung für innere Medizin II, Christian-Albrechts-Universität Kiel.
Klin Wochenschr. 1988 Dec 1;66(23):1160-6. doi: 10.1007/BF01727662.
One hundred and fourty-nine axillary lymph node metastases of 35 female patients with invasive breast carcinomas were investigated immunohistochemically for their estrogen receptor (ER)-status. In addition, proliferative activity of the metastatic deposits was determined with the monoclonal antibody Ki-67. Twenty-four primary tumours were ER+ and 11 ER-. Lymph node metastases were ER+ in 21 of the 24 cases where the primary tumour was ER+. In 10 of the 11 cases with ER- primary tumours, the metastases were also ER-. In any given case, the lymph node metastases proved to be either all ER+ or all ER-. Negative ER-status was found to be related to higher numbers of axillary node metastases and higher maximum proliferative activity of the metastatic tumours. Follow-up at 2 years after diagnosis revealed a significantly lower incidence of distant metastases in patients with ER+ primary tumours.
对35例浸润性乳腺癌女性患者的149个腋窝淋巴结转移灶进行免疫组织化学研究，以确定其雌激素受体（ER）状态。此外，用单克隆抗体Ki-67测定转移灶的增殖活性。24例原发性肿瘤为ER阳性，11例为ER阴性。在原发性肿瘤为ER阳性的24例病例中，21例的淋巴结转移灶为ER阳性。在原发性肿瘤为ER阴性的11例病例中，10例的转移灶也为ER阴性。在任何给定病例中，淋巴结转移灶均被证明要么全为ER阳性，要么全为ER阴性。发现ER阴性状态与腋窝淋巴结转移数量较多以及转移肿瘤的最大增殖活性较高有关。诊断后2年的随访显示，原发性肿瘤为ER阳性的患者远处转移发生率显著较低。
