Krieger W J, ter Welle H F, Fiolet J W, Janse M J
Basic Res Cardiol. 1984 Sep-Oct;79(5):562-71. doi: 10.1007/BF01910485.
We studied the effect of tonicity of the perfusate during reperfusion after global ischemia, in both the rat and the porcine heart. After 50 min, tissue osmolality increased by about 40 mOsm/kg. Normotonic as well as hypertonic reperfusion resulted in limited areas of "no-reflow". Metabolic restoration after reperfusion was not dependent on the tonicity of the perfusate, nor was recovery of contractility. Hypertonic reperfusion induced a higher coronary flow rate. In porcine hearts, scatter of metabolic data indicated inhomogeneity of reperfused tissue. The results differ substantially from data obtained after reperfusion of regionally ischemic hearts. Reasons for these differences are discussed.
我们研究了在大鼠和猪心脏整体缺血后再灌注期间灌注液张力的影响。50分钟后，组织渗透压增加了约40毫摩尔/千克。等渗和高渗再灌注均导致有限区域的“无复流”。再灌注后的代谢恢复不依赖于灌注液的张力，收缩力的恢复也不依赖于此。高渗再灌注诱导更高的冠状动脉血流速度。在猪心脏中，代谢数据的离散表明再灌注组织的不均匀性。这些结果与局部缺血心脏再灌注后获得的数据有很大差异。讨论了这些差异的原因。
