Azizi F, Amini M, Arbab P
Endocrine Research Centre, Taleghani Medical Centre, Shaheed Beheshti University of Medical Sciences, Eveen Tehran, I.R. Iran.
Exp Clin Endocrinol. 1993;101(5):303-6. doi: 10.1055/s-0029-1211248.
In order to evaluate the time course of changes in serum concentration of thyroid hormones, cortisol and ACTH in patients exposed to chemical weapons containing sulfur mustard, we measured serum concentrations of hormones on the first, third and fifth week following injury in 13 soldiers and compared them to the results obtained from 34 control men. Free T4 and T3 indices were decreased and rT3, cortisol and ACTH were increased in the first week following exposure. There was a subnormal TSH response to TRH in 2 of 3 men tested. Except for an increase in FT4I and a decrease in TSH by the third week, and a steady decline in serum cortisol, serum hormone concentrations were unchanged until the fifth week after injury. The decline in serum cortisol occurred despite a constant increase in serum ACTH. By the fifth week only 1 of 13 men had serum cortisol levels > 10 micrograms/dl. We conclude that exposure to chemical weapons containing sulfur mustard results in alterations in serum concentrations of thyroid and adrenal hormones and ACTH, resembling changes seen in burn trauma. Some evidence of direct effects of mustard on endocrine glands exist.
为了评估接触含硫芥气化学武器的患者血清中甲状腺激素、皮质醇和促肾上腺皮质激素（ACTH）浓度的变化时间进程，我们测量了13名士兵受伤后第一周、第三周和第五周的血清激素浓度，并将其与34名对照男性的结果进行比较。接触后第一周，游离T4和T3指数降低，反三碘甲状腺原氨酸（rT3）、皮质醇和ACTH升高。在接受测试的3名男性中，有2名对促甲状腺激素释放激素（TRH）的促甲状腺激素（TSH）反应低于正常水平。除了第三周游离甲状腺素指数（FT4I）升高和TSH降低，以及血清皮质醇持续下降外，血清激素浓度在受伤后第五周前均无变化。尽管血清ACTH持续升高，但血清皮质醇仍下降。到第五周时，13名男性中只有1人的血清皮质醇水平>10微克/分升。我们得出结论，接触含硫芥气化学武器会导致血清中甲状腺和肾上腺激素以及ACTH浓度发生改变，类似于烧伤创伤中所见的变化。有证据表明芥气对内分泌腺有直接影响。
