Park B K, Scott A K, Wilson A C, Haynes B P, Breckenridge A M
Br J Clin Pharmacol. 1984 Nov;18(5):655-62. doi: 10.1111/j.1365-2125.1984.tb02526.x.
The disposition of vitamin K1, after intravenous (10 mg) and oral doses (10 mg and 50 mg) was studied in six healthy male subjects. After intravenous administration, the plasma concentration-time profile was adequately fitted with an average terminal half-life of 1.7 h. After oral administration (10 mg and 50 mg) the availability of vitamin K showed marked inter-individual variation (10-63%). With the higher dose intra-individual variation was also observed. Experiments in brodifacoum-anticoagulated rabbits demonstrate that the duration of action of a pharmacological dose (10 mg/kg) is short (9 h) and that high plasma concentrations (ca 1 microgram/ml) of the vitamin are required to drive clotting factor synthesis during maximum coumarin anticoagulation. Taken collectively, these data indicate that the short duration of action of vitamin K, frequently observed in cases of coumarin poisoning, is a consequence of requirements for high vitamin K concentrations and rapid clearance of the vitamin.
在6名健康男性受试者中研究了静脉注射（10毫克）和口服剂量（10毫克和50毫克）后维生素K1的处置情况。静脉给药后，血浆浓度-时间曲线拟合良好，平均终末半衰期为1.7小时。口服给药（10毫克和50毫克）后，维生素K的生物利用度显示出明显的个体间差异（10%-63%）。使用较高剂量时也观察到个体内差异。在溴敌隆抗凝兔身上进行的实验表明，药理剂量（10毫克/千克）的作用持续时间较短（9小时），并且在最大程度的香豆素抗凝期间，需要高血浆浓度（约1微克/毫升）的维生素来驱动凝血因子合成。综合来看，这些数据表明，在香豆素中毒病例中经常观察到的维生素K作用持续时间短，是需要高维生素K浓度以及维生素快速清除的结果。
