[氢化可的松对豚鼠肝脏细胞色素P-450系统及食物过敏反应强度的影响]
[Effect of hydrocortisone on the liver cytochrome P-450 system and the intensity of food anaphylaxis in guinea pigs].
作者信息
Marokko I N, Khlopushina T G, Lysenkova E M, Kovalev I E, Shaternikov V A
出版信息
Biull Eksp Biol Med. 1984 Dec;98(12):713-5.
Intraperitoneal injection of hydrocortisone in single daily doses from 0.1 to 25.0 mg/kg, for 3 days was followed by reduced activity of liver microsomal monooxygenases and decreased content of cytochrome P-450 and b5. Hydrocortisone diminished the activity of the liver cytochrome P-450 system in vivo that significantly potentiated hexenal sleep. The hydrocortisone-inhibited activity of the liver chromosome P-450 system was followed by intensified food anaphylaxis in guinea-pigs.
连续3天每天腹腔注射剂量为0.1至25.0毫克/千克的氢化可的松，随后肝微粒体单加氧酶活性降低，细胞色素P - 450和b5含量减少。氢化可的松在体内降低了肝细胞色素P - 450系统的活性，这显著增强了己醛诱导的睡眠。氢化可的松对肝染色体P - 450系统活性的抑制作用，随后在豚鼠中引发了食物过敏反应增强。
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