阿托品和东莨菪碱的摩尔体积与其各自效力的关系。
The molal volumes of atropine and hyoscine in relation to their respective potencies.
作者信息
Cohen S, Haberman F
出版信息
Br J Pharmacol. 1984 Nov;83(3):807-11. doi: 10.1111/j.1476-5381.1984.tb16236.x.
Abstract
The partial molal volumes, V2, at infinite dilution of atropine and hyoscine were determined in each of eight different solvents having cohesive energy densities in the range 64 to 144 cal cm-3. V2 for hyoscine in a given solvent was invariably and significantly smaller than that of atropine in the same solvent. The difference being 1.58 cm3 mol-1 in the least polar solvent (n-propylbenzene) and 4.29 cm3 mol-1 in the most polar one (acetonitrile) in the series studied. It is proposed that the lower affinity of atropine relative to that of hyoscine for the muscarinic cholinoceptor could be accounted for by the relative increase in enthalpy in the adsorption of atropine to the receptor with respect to the same process with hyoscine.
摘要
在八种内聚能密度范围为64至144 cal cm-3的不同溶剂中，分别测定了阿托品和东莨菪碱在无限稀释时的偏摩尔体积V2。在给定溶剂中，东莨菪碱的V2始终且显著小于阿托品的V2。在所研究的系列中，在极性最小的溶剂（正丙基苯）中差异为1.58 cm3 mol-1，在极性最大的溶剂（乙腈）中差异为4.29 cm3 mol-1。有人提出，阿托品相对于东莨菪碱对毒蕈碱胆碱能受体的亲和力较低，可能是由于阿托品与受体吸附过程中的焓相对于东莨菪碱的相同过程有所增加。
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