Liron Z, Cohen S
J Pharm Sci. 1983 May;72(5):499-504. doi: 10.1002/jps.2600720506.
A procedure is described for the simultaneous determination of molal volumes (v02) and solubility parameters (delta) of compounds of medicinal interest. These include alkanoic acids of various chain length and branching (some solid at room temperature), cholesterol, and cholesteryl esters. The procedure is based on the determination of partial molal volumes (v2) from high-precision density measurements of dilute solutions of these compounds in reference solvents, which range in polarity from carbon tetrachloride (delta = 8.6) to nitrobenzene (delta = 10.0). In some cases, the present results do not agree with values of delta published in the literature. Values calculated from group contributions proposed by other authors are prone to error particularly in the case of branched acids and cholesteryl esters.
本文描述了一种同时测定具有药用价值化合物的摩尔体积（v02）和溶解度参数（δ）的方法。这些化合物包括各种链长和支化的链烷酸（有些在室温下为固体）、胆固醇和胆固醇酯。该方法基于通过对这些化合物在极性范围从四氯化碳（δ = 8.6）到硝基苯（δ = 10.0）的参比溶剂中的稀溶液进行高精度密度测量来测定偏摩尔体积（v2）。在某些情况下，本研究结果与文献中公布的δ值不一致。由其他作者提出的基团贡献计算值容易出错，尤其是在支链酸和胆固醇酯的情况下。
