Raja S N, Campbell J N, Meyer R A
Brain. 1984 Dec;107 ( Pt 4):1179-88. doi: 10.1093/brain/107.4.1179.
Characteristics of primary (within the area of injury) and secondary (outside the area of injury) hyperalgesia were determined after a heat injury applied to the glabrous skin of the hand in 8 human volunteers. The heat injury consisted of two burns (53 degrees C, 30 s) applied over an area 7.5 mm in diameter separated (centre to centre) by a 2 cm interval. Following the injury, a zone of hyperalgesia to mechanical stimuli measuring 20.1 +/- 3.6 cm2 (mean +/- SEM) developed in an area surrounding and including the burns. Within this zone, the pain threshold for mechanical stimuli decreased significantly by a similar amount for all areas tested (12.0 +/- 1.1 bars to 5.2 +/- 0.5 bars). Hyperalgesia to heat occurred only within the area of the burns. The heat pain threshold decreased and total ratings of heat pain increased significantly. In contrast, there was decreased pain to heat stimuli between the two burn sites, and no change in painfulness of the heat stimuli at other areas within the zone of hyperalgesia to mechanical stimuli. Particularly notable was the coexistence of hypalgesia to heat stimuli and hyperalgesia to mechanical stimuli in the uninjured region between the two burn sites. These results indicate that the characteristics of primary and secondary hyperalgesia differ and also suggest that the mechanism for hyperalgesia to mechanical and thermal stimuli differ.
在8名人类志愿者的手部无毛皮肤上施加热损伤后，确定了原发性（损伤区域内）和继发性（损伤区域外）痛觉过敏的特征。热损伤包括在直径7.5毫米的区域上施加两次烧伤（53摄氏度，30秒），两次烧伤的中心间距为2厘米。损伤后，在包括烧伤部位及其周围的区域形成了一个对机械刺激痛觉过敏的区域，面积为20.1±3.6平方厘米（平均值±标准误）。在这个区域内，所有测试区域的机械刺激疼痛阈值均显著降低，且降低幅度相似（从12.0±1.1巴降至5.2±0.5巴）。对热的痛觉过敏仅发生在烧伤区域内。热痛阈值降低，热痛的总体评分显著增加。相比之下，两个烧伤部位之间对热刺激的疼痛减轻，在对机械刺激痛觉过敏区域内的其他区域，热刺激的疼痛程度没有变化。特别值得注意的是，在两个烧伤部位之间的未损伤区域，存在对热刺激的痛觉减退和对机械刺激的痛觉过敏同时存在的情况。这些结果表明原发性和继发性痛觉过敏的特征不同，也表明对机械和热刺激的痛觉过敏机制不同。
