Mallett A K, Rowland I R, Cottrell R C, Gangolli S D
Cancer Lett. 1984 Dec;25(2):231-5. doi: 10.1016/s0304-3835(84)80050-6.
The role of the gastrointestinal microflora in the nitrate-dependent formation of nitrosoproline was assessed in control and antibiotic-treated rats. Urinary nitrosoproline excretion as an index of in vivo nitrosamine formation was shown to be unaffected by bacterial decontamination of the alimentary tract, and proceeded in the absence of detectable nitrate reductase activity in the intestinal contents. These observations suggest that the gut microflora are not required for the formation of nitrosamino acid from nitrate and proline.
在对照大鼠和经抗生素处理的大鼠中评估了胃肠道微生物群在亚硝基脯氨酸的硝酸盐依赖性形成中的作用。尿中亚硝基脯氨酸排泄作为体内亚硝胺形成的指标，显示不受消化道细菌净化的影响，并且在肠内容物中不存在可检测到的硝酸盐还原酶活性的情况下仍会发生。这些观察结果表明，从硝酸盐和脯氨酸形成亚硝基氨基酸不需要肠道微生物群。
