Niimoto M, Yamagata S, Toge T, Harada T, Ikeda H, Hattori T
Jpn J Surg. 1978 Mar;8(1):1-9. doi: 10.1007/BF02469329.
A combination of MFC (Mitomycin-C, 5-FU and Cytosine arabinoside) was administered to 32 gastric cancer patients and study was made of the therapeutic efficacy in relation to the histological pattern. In evaluation based on the degree of cancer cell infiltration (INF), chemotherapy was more effective in cases with INF alpha and beta than those with INF gamma. As for the grade of follicular hyperplasia in regional lymph nodes of gastric cancer, the higher was the grade, the more effective was the chemotherapy. However, a significant relationship could not be observed between histological pattern of stromal reaction of the gastric cancer and clinical effects of chemotherapy. The grade of lymphocyte infiltration or connective tissue reaction in the stroma was not related with the therapeutic effects. No relationship was also obtained between the grade of sinus histiocytosis of lymphoid reaction in the lymph nodes and therapeutic effects.
对32例胃癌患者施用丝裂霉素-C、5-氟尿嘧啶和阿糖胞苷的联合方案，并研究了其与组织学模式相关的治疗效果。在基于癌细胞浸润程度（INF）的评估中，化疗对INFα和β型病例的效果比对INFγ型病例更有效。至于胃癌区域淋巴结的滤泡增生程度，程度越高，化疗效果越显著。然而，未观察到胃癌间质反应的组织学模式与化疗临床效果之间存在显著关系。间质中淋巴细胞浸润或结缔组织反应的程度与治疗效果无关。淋巴结中淋巴反应的窦组织细胞增生程度与治疗效果之间也未发现相关性。
