Osipova L A
Eksp Onkol. 1984;6(2):23-6.
Sensitivity of hepatocytes to the proliferative stimulus (partial hepatectomy) and mitoinhibitory effect of carcinogen (toxic dose after operation) was studied during hepatic carcinogenesis induced by the chronic administration of diethylnitrosamine. At early stages of hepatocarcinogenesis (4-6 weeks of carcinogen treatment) in the rat liver tissue there appears and then increases a subpopulation of hepatocytes insensible to proliferation mediators. The cell number in this subpopulation essentially increased in the period preceding the development of microscopically detected neoplastic nodules.
在通过慢性给予二乙基亚硝胺诱导肝癌发生的过程中，研究了肝细胞对增殖刺激（部分肝切除术）的敏感性以及致癌物（术后毒性剂量）的有丝分裂抑制作用。在大鼠肝癌发生的早期阶段（致癌物处理4 - 6周），肝组织中出现并随后增加了对增殖介质不敏感的肝细胞亚群。在显微镜下检测到的肿瘤结节形成之前的时期，该亚群中的细胞数量显著增加。
