Holloway B R, Davidson R G, Freeman S, Wheeler H, Stribling D
Int J Obes. 1984;8(4):295-303.
The post-natal development of interscapular brown adipose tissue (BAT) was studied in the guinea pig by monitoring changes in DNA, triglycerides and mitochondrial protein as well as the activity of cytochrome oxidase and atractyloside insensitive GDP-binding. The results demonstrate that neonatal brown fat develops into a tissue with the gross characteristics of white adipose tissue. In this respect the post-natal development of guinea pig BAT is analogous to that of the tissue in man. Furthermore the apparent transformation is not irreversible since cold exposure (+4 degrees C) of adult guinea pigs for six weeks resulted in restoration of cytochrome oxidase, GDP-binding, etc, to levels characteristic of neonatal BAT. However, the interscapular fat pad temperature response to noradrenaline and the presence of 32 000 mol. wt mitochondrial inner membrane protein indicate that the tissue retains thermogenic activity even in warm acclimated adult guinea pigs.
通过监测DNA、甘油三酯、线粒体蛋白的变化以及细胞色素氧化酶活性和对苍术苷不敏感的GDP结合活性，对豚鼠肩胛间棕色脂肪组织（BAT）的产后发育进行了研究。结果表明，新生棕色脂肪发育成具有白色脂肪组织总体特征的组织。在这方面，豚鼠BAT的产后发育与人的该组织类似。此外，这种明显的转变并非不可逆转，因为成年豚鼠在4℃冷暴露六周后，细胞色素氧化酶、GDP结合等恢复到新生BAT的特征水平。然而，肩胛间脂肪垫对去甲肾上腺素的温度反应以及32000分子量线粒体内膜蛋白的存在表明，即使在温暖适应的成年豚鼠中，该组织仍保留产热活性。
