Matthay M A, Eschenbacher W L, Goetzl E J
J Clin Immunol. 1984 Nov;4(6):479-83. doi: 10.1007/BF00916578.
The possible contribution of metabolites of arachidonic acid to the increased permeability of the alveolar-capillary barrier in the adult respiratory distress syndrome was examined by quantifying the pulmonary edema fluid concentrations of lipoxygenase and cyclooxygenase products. The concentration of leukotriene D4 in pulmonary edema fluid of 10 patients with the adult respiratory distress syndrome (18.5 +/- 6.8 pmol/ml; mean +/- SD), assessed by specific radioimmunoassay after isolation of the mediator, was significantly higher (P less than 0.001) than that of five patients with cardiogenic pulmonary edema (4.4 +/- 1.1 pmol/ml). The concentrations of leukotrienes B4 and C4, prostaglandin E2, and thromboxane B2 in edema fluid were not significantly different in the adult respiratory distress syndrome patients than in the other subjects with pulmonary edema. The edema fluid concentration of leukotriene D4 correlated with the ratio of edema fluid to plasma concentrations of albumin (r = 0.64). Leukotriene D4 thus may contribute to the permeability defect which allows an accumulation of protein-rich alveolar fluid in the adult respiratory distress syndrome.
通过定量测定肺水肿液中脂氧合酶和环氧化酶产物的浓度，研究了花生四烯酸代谢产物对成人呼吸窘迫综合征中肺泡 - 毛细血管屏障通透性增加的可能作用。在分离出介质后，通过特异性放射免疫测定法评估，10例成人呼吸窘迫综合征患者肺水肿液中白三烯D4的浓度（18.5±6.8 pmol/ml；平均值±标准差）显著高于（P＜0.001）5例心源性肺水肿患者（4.4±1.1 pmol/ml）。成人呼吸窘迫综合征患者水肿液中白三烯B4、C4、前列腺素E2和血栓素B2的浓度与其他肺水肿患者相比无显著差异。白三烯D4的水肿液浓度与水肿液与血浆白蛋白浓度之比相关（r = 0.64）。因此，白三烯D4可能导致通透性缺陷，使得成人呼吸窘迫综合征中富含蛋白质的肺泡液积聚。
