Gordon L A, Orell S R
J Am Acad Dermatol. 1984 Dec;11(6):1082-6. doi: 10.1016/s0190-9622(84)70263-5.
Cytologic and histopathologic diagnoses were assessed independently without clinical details in 150 lesions from 112 consecutive patients. Nine of the lesions (6%) could not be evaluated cytologically because of unsatisfactory smears. Correct cytodiagnosis was obtained in 125 of 141 (89%) evaluable lesions. A solar keratosis with prominent basal cell hyperplasia was incorrectly assessed as a basal cell carcinoma (BCC). Five BCCs were misdiagnosed as squamous atypia, either because the smears were not representative or from inability to distinguish between pleomorphic BCC and severe squamous atypia. An incorrect cytologic diagnosis was thus made in 4% of lesions. Smears from ten lesions (7%) were reported as nondiagnostic for the same reasons. Cytologic diagnosis is simple, rapid, and accurate and is of value in the management of suspected cutaneous BCC.
在连续112例患者的150个病变中，在不了解临床细节的情况下对细胞病理学和组织病理学诊断进行了独立评估。由于涂片不理想，9个病变（6%）无法进行细胞学评估。在141个可评估病变中的125个（89%）获得了正确的细胞诊断。一个具有显著基底细胞增生的日光性角化病被错误地评估为基底细胞癌（BCC）。5个BCC被误诊为鳞状非典型增生，要么是因为涂片不具代表性，要么是无法区分多形性BCC和严重鳞状非典型增生。因此，4%的病变做出了错误的细胞学诊断。10个病变（7%）的涂片因同样原因报告为无法诊断。细胞学诊断简单、快速且准确，在疑似皮肤BCC的管理中具有价值。
