Abalain J H, Amet Y, Daniel J Y, Floch H H
J Steroid Biochem. 1984 Nov;21(5):623-4. doi: 10.1016/0022-4731(84)90341-8.
The uropygial gland of the quail, a sebaceous-like gland, has been proven to be androgen-dependent. Waxes secreted by this gland consist of fatty acids esterified by alkane-2,3-diols [12]. In castrated quails, the relative concentration of dodecane diol was enhanced after testosterone treatment; but 5 alpha-DHT could not evoke any increase in the relative concentration of dodecane diol. It is not possible from our present results to know if this lack of gland response to DHT administration is related to a high level of DHT metabolism in the gland cells or to a decreased affinity of the androgen receptor for DHT. However, because of the high similarity existing between uropygial gland of birds and mammalian sebaceous glands, these results give rise to the question of the true role of DHT in mammalian sebaceous glands.
鹌鹑的尾脂腺是一种类似皮脂腺的腺体，已被证明依赖雄激素。该腺体分泌的蜡由烷烃 - 2,3 - 二醇酯化的脂肪酸组成[12]。在去势鹌鹑中，睾酮处理后十二烷二醇的相对浓度增加；但5α - 双氢睾酮不会引起十二烷二醇相对浓度的任何增加。从我们目前的结果尚无法得知该腺体对双氢睾酮给药缺乏反应是与腺细胞中双氢睾酮的高代谢水平有关，还是与雄激素受体对双氢睾酮的亲和力降低有关。然而，由于鸟类尾脂腺与哺乳动物皮脂腺之间存在高度相似性，这些结果引发了双氢睾酮在哺乳动物皮脂腺中真正作用的问题。
