Grieco C, Silipo C, Vittoria A
Farmaco Sci. 1976 Nov;31(11):824-44.
The basic principles and developments on which the Hansch multiple parameter approach depends are described. A correlation analysis on the antibacterial activity of 2-Y-4-(X-phenyl)-3H-1,5-benzodiazepines is discussed. The use of indicator varioables is shown to greatly increase one's ability to formulate quantitative structure-activity relationships. This approach allows one to carry out objective studies of massive amounts of chemical and biological data.
描述了汉施多参数方法所依赖的基本原理和发展情况。讨论了对2-Y-4-（X-苯基）-3H-1,5-苯并二氮杂卓类化合物抗菌活性的相关分析。结果表明，使用指示变量能大大提高构建定量构效关系的能力。这种方法使人们能够对大量化学和生物学数据进行客观研究。
