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血浆置换治疗胆汁淤积性顽固性瘙痒

Plasmaperfusion for the treatment of intractable pruritus of cholestasis.

作者信息

Lauterburg B H, Pineda A A, Dickson E R, Baldus W P, Taswell H F

出版信息

Mayo Clin Proc. 1978 Jun;53(6):403-7.

PMID:651386
Abstract

A patient with primary biliary cirrhosis and intractable pruritus was treated with plasmaperfusion of charcoal-coated glass beads on two occasions. The procedures were well tolerated and resulted in the removal of about 70% (494 mumol) of the estimated chenic acid pool. There was, in addition, pronounced amelioration of the pruritus which enabled the patient to sleep through the night without awakening because of itching. The pruritus, however, did not disappear and gradually returned to its preperfusion intensity by the end of the third week after perfusion.

摘要

一名原发性胆汁性肝硬化伴顽固性瘙痒的患者接受了两次涂有活性炭的玻璃珠血浆灌注治疗。治疗过程耐受性良好,约70%(494微摩尔)的估计胆酸池被清除。此外,瘙痒症状明显改善,患者能够夜间安睡而不因瘙痒醒来。然而,瘙痒并未消失,在灌注后第三周结束时逐渐恢复到灌注前的强度。

相似文献

1
Plasmaperfusion for the treatment of intractable pruritus of cholestasis.血浆置换治疗胆汁淤积性顽固性瘙痒
Mayo Clin Proc. 1978 Jun;53(6):403-7.
2
Treatment of pruritus of cholestasis by plasma perfusion through USP-charcoal-coated glass beads.通过美国药典级活性炭包被玻璃珠进行血浆灌注治疗胆汁淤积性瘙痒。
Lancet. 1980 Jul 12;2(8185):53-5. doi: 10.1016/s0140-6736(80)92938-4.
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Depletion of bile acids and bilirubin in dogs with biliary obstruction by plasmaperfusion of USP-charcoal-coated glass beads.
Int J Artif Organs. 1980 Sep;3(5):281-5.
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Efficacy of molecular adsorbent recirculating system for the treatment of intractable pruritus in cholestasis.分子吸附再循环系统治疗胆汁淤积性顽固性瘙痒的疗效
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Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease.血液灌流治疗胆汁淤积性肝病药物难治性瘙痒症
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Removal of bile acids and bilirubin by plasmaperfusion of U.S.P. charcoal-coated glass beads.通过美国药典规定的涂有活性炭的玻璃珠进行血浆灌注去除胆汁酸和胆红素。
J Lab Clin Med. 1979 Oct;94(4):585-92.
7
Extracorporeal albumin dialysis: a procedure for prolonged relief of intractable pruritus in patients with primary biliary cirrhosis.体外白蛋白透析:一种用于长期缓解原发性胆汁性肝硬化患者顽固性瘙痒的方法。
Am J Gastroenterol. 2004 Jun;99(6):1105-10. doi: 10.1111/j.1572-0241.2004.30204.x.
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Plasmaperfusion and studies of copper metabolism in benign recurrent cholestasis: novel procedures in a rare syndrome.血浆灌注与良性复发性胆汁淤积症铜代谢研究:一种罕见综合征的新方法
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Plasma separation and anion adsorption transiently relieve intractable pruritus in primary biliary cirrhosis.血浆分离和阴离子吸附可短暂缓解原发性胆汁性肝硬化的顽固性瘙痒。
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Pruritus of cholestasis treated with plasma perfusion.血浆灌注治疗胆汁淤积性瘙痒症。
Am J Gastroenterol. 1981 Oct;76(4):330-7.

引用本文的文献

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The Liver Disease Symptom Index 2.0; validation of a disease-specific questionnaire.肝病症状指数2.0;一种疾病特异性问卷的验证
Qual Life Res. 2004 Oct;13(8):1469-81. doi: 10.1023/B:QURE.0000040797.17449.c0.
2
Pruritus.
Curr Treat Options Gastroenterol. 1999 Dec;2(6):451-456. doi: 10.1007/s11938-999-0048-8.
3
Pruritus associated with cholestasis. A review of pathogenesis and management.胆汁淤积相关的瘙痒。发病机制与管理综述。
Dig Dis Sci. 1994 Jan;39(1):1-8. doi: 10.1007/BF02090052.
4
Plasma exchange in primary biliary cirrhosis.原发性胆汁性肝硬化中的血浆置换
Postgrad Med J. 1981 Jul;57(669):433-5. doi: 10.1136/pgmj.57.669.433.
5
Altered bile acid metabolism in primary biliary cirrhosis.原发性胆汁性肝硬化中胆汁酸代谢的改变。
Dig Dis Sci. 1981 May;26(5):394-401. doi: 10.1007/BF01313580.