Dyer R S, Muller K E, Janssen R, Barton C N, Boyes W K, Benignus V A
Neurobehav Toxicol Teratol. 1984 Sep-Oct;6(5):363-8.
Long-Evans hooded rats were exposed to 1000 ppm toluene or 0 ppm toluene 6 hr/day, 5 days/week for 30 days. Following removal from the exposure conditions (18-26 hr) flash-evoked potentials were recorded to paired light flashes and pentylenetetrazol (PTZ) seizure properties were examined. No alterations were found in the response to the first flash, but alterations in the recoverability of the nervous system were demonstrated by significant latency shifts in the response to the second of the paired flashes, using first flash latencies as covariates. No significant alterations were found in PTZ seizures. The data indicated that at these exposure levels toluene produced a small but significant alteration in brain function, even after toluene had been completely metabolized.
将长 Evans 戴帽大鼠每天暴露于 1000 ppm 甲苯或 0 ppm 甲苯环境中，每天 6 小时，每周 5 天，持续 30 天。在脱离暴露环境（18 - 26 小时）后，记录对成对闪光的闪光诱发电位，并检测戊四氮（PTZ）诱发癫痫的特性。对第一次闪光的反应未发现改变，但以第一次闪光潜伏期作为协变量，通过对成对闪光中第二次闪光反应的显著潜伏期变化，证明了神经系统恢复能力的改变。在 PTZ 诱发癫痫方面未发现显著改变。数据表明，即使甲苯已完全代谢，在这些暴露水平下，甲苯仍会对脑功能产生微小但显著的改变。
