Herman Z S, Kowalski J, Trzeciak H, Przewłocki R
Neuropeptides. 1984 Nov;4(6):497-505. doi: 10.1016/0143-4179(84)90093-3.
Male Wistar rats were injected with fluphenazine /FLU/ i.p. in doses of 1 or 5 mg/kg for twelve months. Striatal met- and leu-enkephalin contents were determined after 1, 3, 6, 9 and 12 months of treatment, and one week after the drug withdrawal following a 12-month treatment, Enkephalin levels were significantly increased with slight fluctuations in some months and returned to normal one week after the last neuroleptic dose following a 12-month administration. Apomorphine, but not naloxone, prevented elevation of enkephalin levels after a one month FLU administration. Our findings confirm previous observations that prolonged disturbances in functions of the dopaminergic mechanism result in specific disturbances in the endogenous opioid peptide content, release and biosynthesis, and demonstrate that enkephalins are one of the factors with take part in the mechanism of neuroleptic action during a long-term treatment.
雄性Wistar大鼠腹腔注射氟奋乃静（FLU），剂量为1或5毫克/千克，持续十二个月。在治疗1、3、6、9和12个月后，以及在12个月治疗后停药一周后，测定纹状体中甲硫氨酸脑啡肽和亮氨酸脑啡肽的含量。脑啡肽水平显著升高，在某些月份有轻微波动，在12个月给药后的最后一剂抗精神病药物后一周恢复正常。在氟奋乃静给药一个月后，阿扑吗啡可预防脑啡肽水平升高，但纳洛酮则不能。我们的研究结果证实了先前的观察结果，即多巴胺能机制功能的长期紊乱会导致内源性阿片肽含量、释放和生物合成的特定紊乱，并表明脑啡肽是长期治疗期间参与抗精神病药物作用机制的因素之一。
