Matousek M, Hjalmarson A, Koch J, Petersén I
Neuropsychobiology. 1984;12(1):55-9. doi: 10.1159/000118110.
The aim of this study was to investigate the changes of vigilance caused by beta-blockers. A recently developed method to measure the vigilance fluctuations, based on the EEG spectra, was employed together with self-rating. Repeated vigilance measurements were made in 20 healthy volunteers before and after administration of placebo, propranolol and metoprolol in random sequence. Both EEG analysis and self-rating confirmed that the vigilance level was significantly decreased after administration of beta-blockers compared to placebo. No significant difference between propranolol and metoprolol could be found. The results suggest that the decrease in systolic blood pressure after beta-blockade may be responsible for the drug-induced drowsiness. However, some of the observations made in the study can be interpreted as indirect proof that central mechanisms are also involved, and that both propranolol and metoprolol have sedative properties comparable to those observed with conventional psychotropic drugs.
本研究旨在调查β受体阻滞剂引起的警觉性变化。采用了一种最近开发的基于脑电图频谱测量警觉性波动的方法，并结合自我评分。对20名健康志愿者按随机顺序在服用安慰剂、普萘洛尔和美托洛尔之前和之后进行了重复的警觉性测量。脑电图分析和自我评分均证实，与安慰剂相比，服用β受体阻滞剂后警觉性水平显著降低。未发现普萘洛尔和美托洛尔之间有显著差异。结果表明，β受体阻滞剂治疗后收缩压的降低可能是药物引起嗜睡的原因。然而，该研究中的一些观察结果可被解释为间接证据，表明中枢机制也参与其中，并且普萘洛尔和美托洛尔都具有与传统精神药物相当的镇静特性。
