Matousek M
Neuropsychobiology. 1987;17(1-2):118-20. doi: 10.1159/000118348.
The sedative or excitatory effects of drugs are difficult to evaluate in patients with depression, where sleep disturbances and tiredness in the daytime belong to the clinical manifestations of the psychiatric disorder. A refined method of vigilance measurement, based on the EEG spectra, together with proper statistical analysis of the data, is helpful for correct interpretation of the data. In two groups of patients with depression, the intensity of sleep disturbances was considered as a background variable in partial correlations, reflecting the relationships between vigilance and drug concentration in a more specific way. It was shown that the sedative effect of maprotiline interferes with the increased vigilance in the patients, with improved night sleep after treatment. As a result, the patients do not experience decreased vigilance although maprotiline has a sedative action. The results obtained in the patients treated with beta-blockers suggest that the drug itself has no sedative effect but the patients suffer from decreased vigilance in the daytime, caused by the sleep disturbances and depression.
药物的镇静或兴奋作用在抑郁症患者中很难评估，因为睡眠障碍和日间疲劳属于这种精神疾病的临床表现。一种基于脑电图频谱的精确警觉性测量方法，再加上对数据进行适当的统计分析，有助于正确解读数据。在两组抑郁症患者中，睡眠障碍的严重程度在偏相关分析中被视为背景变量，以更具体的方式反映警觉性与药物浓度之间的关系。结果表明，马普替林的镇静作用干扰了患者警觉性的提高，治疗后夜间睡眠有所改善。因此，尽管马普替林有镇静作用，但患者并未出现警觉性下降。在接受β受体阻滞剂治疗的患者中获得的结果表明，药物本身没有镇静作用，但患者由于睡眠障碍和抑郁症而在白天出现警觉性下降。
