Basso-Ricci S, Arioli N, Sacchini V, Lovo G F
Minerva Med. 1984 Nov 10;75(43):2603-7.
Thirty five cases of carcinomas of the skin, presumably induced by ionizing radiation therapy are reported. There was a precise topographic relationship between the site of irradiation and that of onset of tumor; in 31 cases, there were multiple neoplastic foci in the skin area exposed to ionizing radiation; a sufficiently long period of time had elapsed from the time of exposure to ionizing radiation to the clinical diagnosis of induced tumor; cases in which there were cutaneous carcinomas in other parts of the body as well as in the skin area exposed to the radiation were excluded from the series. Almost all patients had been subjected to ionizing radiation for treatment of benign diseases and 29 for arthrosis. The median age of the patients at the time of exposure to the ionizing radiation was 33,33 years. The radiation dose to which the patients had been subjected varied from 10 to 25 Gy; this dose is rather low, however it is in this dose range, according to Gray, a relatively high incidence of induced tumor is verified. The median interval between exposure to ionizing radiation and clinical finding of the tumor was 18.5 years. The carcinomas were observed almost always in the trunk and like spontaneous carcinomas at this site they were almost exclusively basal cell type.
报告了35例推测由电离辐射治疗诱发的皮肤癌病例。照射部位与肿瘤发病部位之间存在精确的地形学关系；31例中，在暴露于电离辐射的皮肤区域有多个肿瘤病灶；从暴露于电离辐射到诱发肿瘤的临床诊断经过了足够长的时间；该系列排除了身体其他部位以及暴露于辐射的皮肤区域存在皮肤癌的病例。几乎所有患者都曾接受电离辐射治疗良性疾病，其中29例治疗关节病。患者暴露于电离辐射时的中位年龄为33.33岁。患者所接受的辐射剂量在10至25 Gy之间变化；然而，根据格雷的研究，该剂量相当低，但正是在这个剂量范围内，证实诱发肿瘤的发生率相对较高。暴露于电离辐射与肿瘤临床发现之间的中位间隔为18.5年。这些癌几乎总是在躯干中观察到，并且与该部位的自发癌一样，几乎都是基底细胞型。
