Porter J B, Jick H, Perera D R, Ylvisaker J T, Hunter J R
Pharmacotherapy. 1984 Nov-Dec;4(6):381-4. doi: 10.1002/j.1875-9114.1984.tb03400.x.
In a 5-year follow-up study of 8553 recipients of cimetidine at Group Health Cooperative of Puget Sound, we examined the frequency of uncommon serious illness requiring hospitalization that may have been drug induced. With the possible exception of one patient with probable drug-induced liver disease, we did not find any instances of serious illness requiring hospitalization that could be attributed with reasonable certainty to cimetidine. This large study provides reassurance that cimetidine is a relatively safe medication.
在对普吉特海湾健康合作组织的8553名西咪替丁接受者进行的一项为期5年的随访研究中，我们调查了可能由药物引起的需要住院治疗的罕见严重疾病的发生频率。除了一名可能患有药物性肝病的患者外，我们没有发现任何需要住院治疗的严重疾病实例可以合理确定地归因于西咪替丁。这项大型研究让人放心，西咪替丁是一种相对安全的药物。
