Gordh T E, Ekman S, Lagerstedt A S
Ups J Med Sci. 1984;89(3):266-73. doi: 10.3109/03009738409179507.
An experimental investigation was carried out concerning the potential neurotoxic effects of clonidine. For this purpose intrathecal or extradural catheters were implanted in dogs. Clonidine at a dose level of 25 micrograms/kg or 12.5 micrograms/kg, or placebo, was then administrated via the catheter once daily for 14 consecutive days. The spinal cord and the nerve roots were then taken for neuropathological analysis. Observation of the neurological behaviour of the animals and the results of the morphological investigation support the conclusion that clonidine under these circumstances does not have any significant neurotoxic effects.
针对可乐定潜在的神经毒性作用进行了一项实验研究。为此，在犬身上植入鞘内或硬膜外导管。然后通过导管每日一次连续14天给予剂量为25微克/千克或12.5微克/千克的可乐定，或给予安慰剂。随后取出脊髓和神经根进行神经病理学分析。对动物神经行为的观察以及形态学研究结果支持以下结论：在这些情况下，可乐定没有任何显著的神经毒性作用。
