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用于外分泌胰腺功能检测的粪便糜蛋白酶:两种新开发检测方法与滴定法的比较

Faecal chymotrypsin for investigation of exocrine pancreatic function: a comparison of two newly developed tests with the titrimetric method.

作者信息

Ehrhardt-Schmelzer S, Otto J, Schlaeger R, Lankisch P G

出版信息

Z Gastroenterol. 1984 Nov;22(11):647-51.

PMID:6516499
Abstract

Two newly developed photometric assays for the estimation of faecal chymotrypsin were studied in comparison with the established titrimetric method in 46 patients and 8 healthy volunteers, who had undergone a secretin-pancreozymin test for diagnostic purposes. The correlation between the two photometric methods and the titrimetric method was good (r = 0.90 and r = 0.91), revealing similar diagnostic sensitivity and specificity. As both photometric methods are less time-consuming and may be performed using a standard laboratory equipment, they offer a good alternative to the established titrimetric method for faecal chymotrypsin estimation.

摘要

在46例患者和8名健康志愿者中,研究了两种新开发的用于评估粪便糜蛋白酶的光度测定法,并与既定的滴定法进行比较。这些患者和志愿者因诊断目的接受了促胰液素-胰酶泌素试验。两种光度测定法与滴定法之间的相关性良好(r = 0.90和r = 0.91),显示出相似的诊断敏感性和特异性。由于两种光度测定法耗时较少,且可使用标准实验室设备进行操作,因此它们为既定的粪便糜蛋白酶滴定法评估提供了一个很好的替代方法。

相似文献

1
Faecal chymotrypsin for investigation of exocrine pancreatic function: a comparison of two newly developed tests with the titrimetric method.用于外分泌胰腺功能检测的粪便糜蛋白酶:两种新开发检测方法与滴定法的比较
Z Gastroenterol. 1984 Nov;22(11):647-51.
2
[Chymotrypsin activity in the stool: comparison of a new photometric technic and the standard titrimetric method].[粪便中胰凝乳蛋白酶活性:一种新的光度测定技术与标准滴定法的比较]
Schweiz Med Wochenschr. 1983 Dec 3;113(48):1794-7.
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[Screening of exocrine pancreatic function (author's transl)].外分泌胰腺功能的筛查(作者译)
Dtsch Med Wochenschr. 1981 Jul 31;106(31-32):983-7. doi: 10.1055/s-2008-1070438.
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A single-specimen fecal chymotrypsin test in the diagnosis of pancreatic insufficiency: correlation with secretin-cholecystokinin and NBT-PABA tests.单样本粪便糜蛋白酶检测在胰腺外分泌功能不全诊断中的应用:与促胰液素-缩胆囊素及对氨基苯甲酰-L-酪氨酸对硝基苯酯检测的相关性
Am J Gastroenterol. 1984 Sep;79(9):697-700.
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Diagnostic value of the fecal chymotrypsin test in pancreatic insufficiency, particularly chronic pancreatitis: correlation with the pancreozymin-secretin test, fecal fat excretion and final clinical diagnosis.粪便糜蛋白酶检测在胰腺功能不全尤其是慢性胰腺炎中的诊断价值:与促胰液素-促胰酶素试验、粪便脂肪排泄及最终临床诊断的相关性
Digestion. 1981;21(6):281-9. doi: 10.1159/000198578.
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[Fecal chymotrypsin concentration in childhood. Normal values, specificity, sensitivity].
Helv Paediatr Acta. 1989 Jun;43(5-6):397-404.
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[Analysis of pancreatic function. Determination of fecal chymotrypsin and the secretin-pancreozymin test. Comparative study].[胰腺功能分析。粪便胰凝乳蛋白酶的测定及促胰液素-促胰酶素试验。比较研究]
Fortschr Med. 1977 Jul 21;95(27):1711-4.
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[Photometric determination of chymotrypsin in feces of the dog. A new method in the diagnosis of chronic exocrine pancreatic insufficiency].
Tierarztl Prax. 1986;14(1):147-52.
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Faecal chymotrypsin: a reliable index of exocrine pancreatic function.粪便糜蛋白酶:外分泌胰腺功能的可靠指标。
Arch Dis Child. 1988 Jul;63(7):785-9. doi: 10.1136/adc.63.7.785.
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[Diagnostic value of fecal elastase test in pancreatic exocrine deficiency].[粪便弹性蛋白酶检测在胰腺外分泌功能不全中的诊断价值]
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引用本文的文献

1
Function tests in the diagnosis of chronic pancreatitis. Critical evaluation.慢性胰腺炎诊断中的功能试验。批判性评价。
Int J Pancreatol. 1993 Aug;14(1):9-20. doi: 10.1007/BF02795225.
2
Laboratory tests in the diagnosis of the chronic pancreatic diseases. Part 5. Stool enzyme measurements.慢性胰腺疾病诊断中的实验室检查。第5部分。粪便酶检测。
Int J Pancreatol. 1988 Mar;3(2-3):101-3. doi: 10.1007/BF02798920.