Orentreich N, Matias J R, Malloy V
Arch Dermatol Res. 1984;276(6):401-5. doi: 10.1007/BF00413362.
The local antiandrogenic action of progesterone was investigated using the androgen-responsive flank organs of adult, sexually mature male Syrian golden hamsters. The effect of the unilateral injections of a micronized suspension of progesterone into the flank organs was analyzed by the measurement of the weight, area of surface pigmentation, and the cross-sectional area of the sebaceous glands. The weekly injections of 5 mg of progesterone for a period of 3 weeks produced approximately 50% reduction in all three parameters in comparison to the controls. The minimal effective dose of 1 mg per week was determined by the injection of progesterone at doses ranging from 0.1 to 5 mg. These effects were localized only to the treated flank organs since the values for the contralateral side were not significantly different from the controls. The local action of progesterone was further demonstrated by the absence of effect on the weight of seminal vesicles and testes of the treated animals in comparison to the controls.
利用成年、性成熟雄性叙利亚金黄地鼠的雄激素反应性胁腹器官，研究了孕酮的局部抗雄激素作用。通过测量重量、表面色素沉着面积和皮脂腺横截面积，分析了向胁腹器官单侧注射微粉化孕酮悬浮液的效果。与对照组相比，每周注射5毫克孕酮，持续3周，所有三个参数均降低了约50%。通过以0.1至5毫克的剂量注射孕酮，确定了每周1毫克的最小有效剂量。这些作用仅局限于治疗的胁腹器官，因为对侧的值与对照组无显著差异。与对照组相比，治疗动物的精囊和睾丸重量没有受到影响，这进一步证明了孕酮的局部作用。
