Girard J, Barbier A, Lafille C
Arch Dermatol Res. 1980;269(3):281-90. doi: 10.1007/BF00406422.
The effect of progesterone on 14C-testosterone metabolism and on 14C-lipid synthesis was studied in two animal sebaceous gland models, hamster flank organ and rat ear skin. Unilateral topical application of progesterone to the female hamster flank organ topically treated with testosterone propionate resulted in localized inhibition of both in vitro 14C-lipogenesis and in vitro conversion of 14C-testosterone to 5 alpha-reduced radio-metabolites. Topical progesterone did not inhibit in vitro 14C-lipogenesis in the male hamster flank organ. Progesterone added in vitro inhibited 14-C-lipogenesis and 14C-testosterone metabolism in male rat ear sebaceous glands. These results lend support to the hypothesis that inhibition of sebaceous gland lipogenesis by progesterone is a consequence of its inhibitory effect on testosterone metabolism. Such a rationale provides a valid explanation for the clinical findings with progesterone reported by other investigators.
在两种动物皮脂腺模型（仓鼠胁腹器官和大鼠耳部皮肤）中研究了孕酮对14C-睾酮代谢及14C-脂质合成的影响。对经丙酸睾酮局部处理的雌性仓鼠胁腹器官单侧局部应用孕酮，导致体外14C-脂肪生成及14C-睾酮向5α-还原放射性代谢物的体外转化均受到局部抑制。局部应用孕酮并未抑制雄性仓鼠胁腹器官的体外14C-脂肪生成。体外添加的孕酮抑制雄性大鼠耳部皮脂腺的14C-脂肪生成及14C-睾酮代谢。这些结果支持了以下假说：孕酮对皮脂腺脂肪生成的抑制作用是其对睾酮代谢的抑制作用的结果。这样的理论依据为其他研究者报道的孕酮的临床研究结果提供了合理的解释。
