Elton M
Biol Psychiatry. 1984 Dec;19(12):1635-49.
A longitudinal investigation of the evoked potential to a warning stimulus, and of the CNV, was conducted with reactive depressives and controls under incentive and nonincentive conditions in a long interstimulus interval paradigm. A smaller group of endogenous depressives were recorded once. The application of multivariate analysis, which controlled for experimental and session effects, indicated that the CNV, as a multiple-component potential, is not capable of distinguishing reactive depressives from controls. Significant univariate interactions involving late CNV area and peak latency were obtained, possibly indexing psychomotor retardation. Analysis of the evoked potential did reveal significant group differences which were explained in terms of main and interaction effects in the P240 and interaction effects involving N120. The findings suggested that groups differed in their responsiveness to experimental demands, and modified their responses differently over time. Mann-Whitney U analysis of endogenous depressives produced no group differences in the CNV measures, but did for N120 amplitude.
在长刺激间隔范式下，于激励和非激励条件下，对反应性抑郁症患者和对照组进行了一项关于警告刺激诱发电位和关联性负变（CNV）的纵向研究。对一小部分内源性抑郁症患者仅进行了一次记录。采用多变量分析来控制实验和时段效应，结果表明，作为多成分电位的CNV无法区分反应性抑郁症患者和对照组。获得了涉及晚期CNV面积和峰值潜伏期的显著单变量交互作用，这可能表明存在精神运动迟缓。诱发电位分析确实揭示了显著的组间差异，这些差异可通过P240中的主效应和交互效应以及涉及N120的交互效应来解释。研究结果表明，各组对实验要求的反应不同，且随时间推移其反应的变化方式也不同。对内源性抑郁症患者进行的曼-惠特尼U分析在CNV测量中未发现组间差异，但在N120波幅上发现了组间差异。
